Nedocromil对多种介质的作用或形成有抑制作用，包括组胺，前列腺素 D2和白三烯 C4。

Nedocromil inhibits the action or formation of multiple mediators. Which including histamine, leukotriene C4 (LTC4), and prostaglandin D2 (PGD2).

Nedocromil suppresses the release of histamine, LTC4, and PGD2 from mast cells challenged with antigen with IC30 values of 2.1 μM, 2.3 μM, and 1.9 μM, respectively. It also has anti-human IgE with IC30 values of 4.7 μM, 1.3 μM, and 1.3 μM, respectively[1].

Nedocromil can obviously improve cardiac function in mice with diabetic cardiomyopathy, but the treatment cannot restore normal function. Nedocromil-treated diabetic mice display obviously improved heart function compared with controls. However, the cardiac function of Nedocromil-treated diabetic mice remains significantly impaired when compared with normal mice [2].

69049-73-6

C19H17NO7

371.34

FPL 59002;尼多克罗

DMSO:16.67 mg/mL (44.89 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years