PF-5190457 是具有选择性的、有效的生长素释放肽受体选择性的反向激动剂(pKi:8.36)。

PF-5190457 is an effective and selective ghrelin receptor inverse agonist (pKi: 8.36).

PF-5190457 has a superior balance of ghrelin receptor pharmacology. It also has off-target selectivity [1].

In human whole and dispersed islets, PF-5190457 has excellent selectivity and demonstrates robust increases in glucose-stimulated insulin secretion[1].

1334782-79-4

C29H32N6OS

512.67

PF-05190457

DMSO:250 mg/mL (487.64 mM),Need ultrasonic
Ethanol:100 mg/mL (195.06 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years