Oglemilast 是一种具有口服活性磷酸二酯酶 4 (PDE4) 抑制剂,对 PDE4D3 的 IC50 为 0.5 nM。Oglemilast 在体外和体内抑制肺细胞浸润,包括嗜酸性粒细胞增多和嗜中性粒细胞减少。Oglemilast 具有应用于炎症性气道疾病的潜力。
产品描述
Oglemilast suppresses pulmonary cell infiltration, including eosinophilia and neutrophilia in vitro and in vivo. Oglemilast is an effective and orally active phosphodiesterase-4 (PDE4) inhibitor (IC50: 0.5 nM for PDE4D3). Oglemilast has the potential for inflammatory airway diseases.
体外活性
For the PDE 4B1 and PDE 4D3 reporter cell lines, Oglemilast has EC50s of 11.4 nM, 4.4 nM, respectively[3].
Cas No.
778576-62-8
分子式
C20H13Cl2F2N3O5S
分子量
516.30
别名
GRC 3886
储存和溶解度
DMSO:3.6mg/mL (7mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years