AMG 579 是一种有效的选择性 PDE10A 抑制剂 (IC50 = 0.1 nM)。

AMG 579 is an efficacious and selective inhibitor of PDE10A (IC50 = 0.1 nM).

AMG 579 statistically reduces PCP-induced behavior in rats within 2 hours. In the PCP-LMA model, the minimum effective dose of AMG 579 was 0.3 mg/kg. AMG 579 has an excellent oral bioavailability of 72% in dogs[1].

1227067-61-9

C25H23N5O3

441.48

AMG-579

DMSO:41.67 mg/mL (94.39 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years