BCL-xL antagonist 2 是一种有效的选择性 BCL-xL 拮抗剂，IC50 为 91 nM，Ki 为 65 nM。 BCL-xL antagonist 2 可诱导癌细胞凋亡，可用于慢性淋巴细胞白血病和非霍奇金淋巴瘤的研究。

Bcl-xL antagonist 2 is an effective and selective antagonist of Bcl-xL with an IC50 of 91 nM and a Ki of 65 nM. Bcl-xL antagonist 2 induces apoptosis in cancer cells and can be used in studies about chronic lymphocytic leukemia and non-Hodgkin’s lymphoma.

Bcl-xL antagonist 2 (1 mg/kg;i.v.) exhibits good PK profile with CL, Vss, t1/2 and F of 0.47 mL/min/kg, 0.16 L/kg, 6.0 h and 16% in rats[1].

1235032-75-3

C21H16N4O3S2

436.51

DMSO:50 mg/mL (114.5 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years