Aβ42-IN-1, compound 1v, is a novel, highly potent and orally bioavailable γ-secretase modulator (GSM). Aβ42-IN-1 highly potently reduced Aβ42 levels with an IC50 value of 0.091 μM without CYP3A4 inhibition. Aβ42-IN-1 shows a sustained pharmacokinetic profile. References: [1]. Sekioka R, et al. Discovery of N-ethylpyridine-2-carboxamide derivatives as a novel scaffold for orally active γ-secretase modulators.Bioorg Med Chem. 2019 Nov 6:115132.

纯度：≥98%