Tomatidine 通过阻断 NF-Κb 和 JNK 信号传导而发挥抗炎作用。它在哺乳动物细胞或秀丽隐杆线虫中激活自噬。

Tomatidine acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling. It activates autophagy either in mammal cells or C elegans.

Staphylococcus aureus (S. aureus) is responsible for difficult-to-treat and relapsing infections and constitutes one of the most problematic pathogens due to its multiple resistances to clinically available antibiotics. Additionally, the ability of S. aureus to develop small-colony variants is associated with a reduced susceptibility to aminoglycoside antibiotics and in vivo persistence. METHODS AND RESULTS: We have recently demonstrated that Tomatidine, a steroid alkaloid isolated from tomato plants, possesses anti-virulence activity against normal strains of S. aureus as well as the ability to potentiate the effect of aminoglycoside antibiotics. In addition, Tomatidine has shown antibiotic activity against small-colony variants of S. aureus. CONCLUSIONS: We herein report the first study of the structure-activity relationship of Tomatidine against S. aureus.

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C27H45NO2

415.65

DMSO:2.86 mg/mL (6.88 mM),Need ultrasonic
0.1 M HCL:< 1 mg/mL (insoluble)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years