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FM19G11
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
FM19G11图片
CAS NO:329932-55-0
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议

产品名称
HIF-1alpha/2alpha Inhibitor
产品介绍
FM19G11 是一种低氧诱导因子 (HIF) α-亚基抑制剂(在低氧诱导的荧光素酶试验中IC50 为 80 nM)。

产品描述

FM19G11 is an inhibitor of hypoxia inducible factor (HIF) α-subunit (IC50 = 80 nM in hypoxia induced luciferase assay).

体外活性

FM19G11 (500 nM) promotes oligodendrocyte differentiation under hypoxic conditions[1]. FM19G11 (300 nM) significantly enhances the pro-apoptotic effect of temozolomide, whereas FM19G11 does not induce apoptosis. In hypoxic GBM-XD, hypoxic T98G, and normoxic T98G cells, FM19G11 (300 nM) significantly inhibited the mRNA level of O6-methylguanine DNA-methyltransferase via the HIF-1α pathway[3].

体内活性

Intramedullary injection of FM19G11 improves locomotion in severe spinal cord injury and induces the expression of GAP43 and RIP at the injury[2].

Cas No.

329932-55-0

分子式

C23H17N3O8

分子量

463.4

别名

HIF-1alpha/2alpha Inhibitor

储存和溶解度

DMSO:90mg/mL (194.2mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years