FM19G11 是一种低氧诱导因子 (HIF) α-亚基抑制剂（在低氧诱导的荧光素酶试验中IC50 为 80 nM）。

FM19G11 is an inhibitor of hypoxia inducible factor (HIF) α-subunit (IC50 = 80 nM in hypoxia induced luciferase assay).

FM19G11 (500 nM) promotes oligodendrocyte differentiation under hypoxic conditions[1]. FM19G11 (300 nM) significantly enhances the pro-apoptotic effect of temozolomide, whereas FM19G11 does not induce apoptosis. In hypoxic GBM-XD, hypoxic T98G, and normoxic T98G cells, FM19G11 (300 nM) significantly inhibited the mRNA level of O6-methylguanine DNA-methyltransferase via the HIF-1α pathway[3].

Intramedullary injection of FM19G11 improves locomotion in severe spinal cord injury and induces the expression of GAP43 and RIP at the injury[2].

329932-55-0

C23H17N3O8

463.4

HIF-1alpha/2alpha Inhibitor

DMSO:90mg/mL (194.2mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years