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Tianeptine sodium
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Tianeptine sodium图片
CAS NO:30123-17-2
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议
25mg电议
100mg电议

产品介绍
噻奈普汀钠是 5-HT 摄取的选择性促进剂。
Cas No.30123-17-2
别名噻奈普汀钠
化学名sodium;7-[(3-chloro-6-methyl-5,5-dioxo-11H-benzo[c][2,1]benzothiazepin-11-yl)amino]heptanoate
Canonical SMILESCN1C2=CC=CC=C2C(C3=C(S1(=O)=O)C=C(C=C3)Cl)NCCCCCCC(=O)[O-].[Na+]
分子式C21H24ClN2NaO4S
分子量458.93
溶解度≥ 22.9mg/mL in DMSO, ≥ 16.27 mg/mL in EtOH with ultrasonic, ≥ 50.3 mg/mL in Water with ultrasonic
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Tianeptine sodium salt is a selective facilitator of 5-HT uptake in vitro and in vivo. IC50 Value:Target: 5-HT ReceptorTianeptine has no affinity for a wide range of receptors, including 5-HT and dopamine (IC50 >10 μM) and has no effect on noradrenalin or dopamine uptake. Antidepressant, analgesic and neuroprotective following systemic administration in vivo.

References:
[1]. Broqua P; Baudrie V; Chaouloff F Differential effects of the novel antidepressant tianeptine on L-5-hydroxytryptophan (5-HTP)-elicited corticosterone release and body weight loss. Eur Neuropsychopharmacol. 1992 Jun;2(2):115-20.
[2]. Orescanin-Dusic Z, et al. Tianeptine's effects on spontaneous and Ca2+-induced uterine smooth muscle contraction. Acta Physiol Hung. 2012 Jun;99(2):140-7.
[3]. Della FP, Abelaira HM, Réus GZ, Ribeiro KF, Antunes AR, Scaini G, Jeremias IC, Dos Santos LM, Jeremias GC, Streck EL, Quevedo J.Tianeptine treatment induces antidepressive-like effects and alters BDNF and energy metabolism in the brain of rats.Behav Brain Res. 2012 Aug 1;233(2):526-35. Epub 2012 May 31.
[4]. Sohn W, Lee OY, Kwon JG, Park KS, Lim YJ, Kim TH, Jung SW, Kim JI.Tianeptine vs amitriptyline for the treatment of irritable bowel syndrome with diarrhea: a multicenter, open-label, non-inferiority, randomized controlled study.Neurogastroenterol Motil. 2012 Sep;24(9):860-e398.
[5]. Orola L, Veidis MV, Sarcevica I, Actins A, Belyakov S, Platonenko A.The effect of pH on polymorph formation of the pharmaceutically active compound tianeptine.Int J Pharm. 2012 Aug 1;432(1-2):50-6. Epub 2012 Apr 30.