CAS NO: | 459-86-9 |
包装 | 价格(元) |
10 mM * 1 mL in Water | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
生物活性 | Mitoguazone (Methylglyoxal-bis(guanylhydrazone)) is a synthetic polycarbonyl derivative with potent antineoplastic activity. Mitoguazone is a brain-penetrant and competitiveS-adenosyl-methionine decarboxylase (SAMDC)inhibitor that disruptspolyamine biosynthesis. Mitoguazone induces cellapoptosis. Mitoguazone inhibitsHIVDNA integration into the cellular DNA in both monocytes and macrophages. Mitoguazone has the potential for acute leukemia, Hodgkin's and non-Hodgkin's lymphoma treatment[1][2][3][4]. | ||||||||||||||||
体外研究 (In Vitro) | Mitoguazone competitively inhibits spermidine synthesis in lymphocytes at concentrations as low as 0.5 μg/mL. Levels of 30 μg/mL or more inhibit protein synthesis and mitochondrial respiration[1]. | ||||||||||||||||
体内研究 (In Vivo) | The influence of different stages of leukemia P388 on the pharmacokinetics of the antineoplastic agent Mitoguazone in mice is investigated. Independent of the tumor stage investigated, the total clearance of mitoguazone is slightly reduced reflecting a moderate increase of AUC in the serum of leukemia-bearing animals. Furthermore, in an advanced tumor stage the drug levels in kidneys, liver, spleen and serum are found to be elevated to some extent in comparison to tumor-free controls in contrast to an earlier stage of leukemia[5]. | ||||||||||||||||
Clinical Trial | |||||||||||||||||
分子量 | 184.20 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C5H12N8 | ||||||||||||||||
CAS 号 | 459-86-9 | ||||||||||||||||
中文名称 | 米托瓜酮 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) | ||||||||||||||||
溶解性数据 | In Vitro: H2O : 50 mg/mL(271.44 mM;ultrasonic and adjust pH to 9 with HCl) 配制储备液
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