CAS NO: | 217171-01-2 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
2mg | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
生物活性 | PD173212 is a selectiveN-type voltage sensitivecalcium channel(VSCC)blocker, with anIC50of 36 nM in IMR-32 assays. | ||||||||||||||||
IC50& Target | IC50: 36 nM (VSCC)[1] | ||||||||||||||||
体外研究 (In Vitro) | PD173212 (PD 173212, 300 nM) potently blocks recombinant B-class (N-type) calcium channel currents 78±7.8%, with an IC50of 74 nM, by whole-cell voltage-clamp techniques. PD 173212 possesses selectivity for non L-type Ca2+channels versus neuronal Na+, K+, and L-type Ca2+channels[1]. | ||||||||||||||||
体内研究 (In Vivo) | PD173212 (30 mg/kg, i.v.) shows moderate efficacy in preventing tonic seizures in the audiogenic seizure model[1]. | ||||||||||||||||
分子量 | 599.85 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C38H53N3O3 | ||||||||||||||||
CAS 号 | 217171-01-2 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : ≥ 100 mg/mL(166.71 mM) *"≥" means soluble, but saturation unknown. 配制储备液
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