包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | NC-III-49-1 is a potentbivalent bromodomain and extraterminal domain (BET)inhibitor. NC-III-49-1 shows binding potential for BRD4-1, BRD4-2, BRD4-T, BRDT-1, BRDT-2, BRDT-T withKdvalues of 0.095, 0.32, 0.29, 0.089, 5.5, 0.058 nM, respectively. NC-III-49-1 shows antiproliferative activity. NC-III-49-1 decreases the expression ofc-Myc[1]. | ||||||||||||||||
IC50& Target[1] |
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体外研究 (In Vitro) | NC-III-49-1 (0-10 μM; 72 h) shows antiproliferative activity with anIC50value of 0.69 nM in MM1.S cells[1]. Cell Viability Assay[1]
Western Blot Analysis[1]
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体内研究 (In Vivo) | NC-III-49-1 shows metabolic stability in human and mouse liver microsomes with an T1/2values of<2.3,<2.3 min, respectively[1]. | ||||||||||||||||
分子量 | 875.02 | ||||||||||||||||
Formula | C44H50N4O11S2 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |