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Levalbuterol
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Levalbuterol图片
CAS NO:34391-04-3
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
左沙丁胺醇
(R)-Albuterol
(R)-Salbutamol
Levosalbutamol
产品介绍
Levalbuterol ((R)-Albuterol; (R)-Salbutamol) 是短效 β2-肾上腺素受体 (β2-adrenergic receptor) 激动剂和 Salbutamol 的活性 R 型对映异构体。Levalbuterol 是一种比 Salbutamol 更有效的支气管扩张试剂,可用于哮喘和慢性阻塞性肺疾病 (COPD) 的研究。
生物活性

Levalbuterol ((R)-Albuterol; (R)-Salbutamol) is a short-acting β2-adrenergic receptoragonist and the active (R)-enantiomer of Salbutamol. Levalbuterol is a more potent bronchodilator than Salbutamol and has the potential for the treatment of COPD[1].

体外研究
(In Vitro)

Levalbuterol (10 μM; 24 hours) induces11β-HSD1mRNA expression, however, it does not influence11β-HSD2expression in airway epithelial cells[1].
Levalbuterol (10 μM; 24 hours) significantly reduces both LPS- and TNF-α-induced NF-κB activity while increasing GRE activation in an 11β-HSD1 dependent manner in a transformed mouse airway epithelial cell line[1].

RT-PCR[1]

Cell Line:Murine Club (MTCC) cells
Concentration:10 μM
Incubation Time:24 hours
Result:Increased11β-HSD1mRNA expression selectively.
体内研究
(In Vivo)

Levalbuterol (subcutaneous injection; 1 mg/kg; 14 days) significantly decreases pulmonary inflammation in OVA mice, demonstrated a decrease in eosinophilia and IgE[3].

Animal Model:C57BL/6 female mice with a pulmonary allergic model[3]
Dosage:1 mg/kg
Administration:Subcutaneous injection; 1 mg/kg; 14 days
Result:Decreased pulmonary inflammation after OVA sensitization.
Clinical Trial
分子量

239.31

Formula

C13H21NO3

CAS 号

34391-04-3

中文名称

左沙丁胺醇

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.