Antitumor agent-86

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Antitumor agent-86

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

Antitumor agent-86 (compound 5a) 抑制 MCF-7 乳腺癌细胞的IC₅₀值为 2.62 μM。Antitumor agent-86 诱导细胞凋亡和细胞周期阻滞，并通过靶向RAS/PI3K/Akt/JNK信号级联显示抗肿瘤活性。

生物活性

Antitumor agent-86 (compound 5a) inhibits MCF-7 breastcancercells with anIC₅₀value of 2.62 μM. Antitumor agent-86 induces cellapoptosisand cell cycle arrest, and shows antineoplastic activity by targetingRAS/PI3K/Akt/JNKsignaling cascades^[1].

体外研究
(In Vitro)

Antitumor agent-86 (0-200 μM；48 h) 剂量依赖性地抑制 MCF-7，MDA-MB-231，Caco-2 和 PANC-1 癌细胞的增殖，IC₅₀值分别为 2.617、6.778、14.8 和 23.58 μM^[1]。
Antitumor agent-86 (2.62 μM；48 h) 诱导细胞凋亡、细胞周期阻滞，降低 MCF-7 细胞的 p-RAS蛋白水平、PI3K 和 Akt 的 mRNA 转录水平和 p-JNK 蛋白的表达^[1]。
Antitumor agent-86 (2.62 μM；48 h) 上调 p21 基因的表达水平^[1]。

Cell Proliferation Assay^[1]

Cell Line:	MCF-7, MDA-MB-231, Caco-2 and PANC-1 cell lines
Concentration:	0-200 μM
Incubation Time:	48 hours
Result:	Dose-dependently suppressed cell proliferation of human cancer cell lines.

Western Blot Analysis^[1]

Cell Line:	MCF-7 cell line
Concentration:	2.62 μM
Incubation Time:	48 hours
Result:	Decreased levels of p-JNK and p-RAS in MCF-7 cells.

Apoptosis Analysis^[1]

Cell Line:	MCF-7 cell line
Concentration:	2.62 μM
Incubation Time:	48 hours
Result:	Induced cell apoptosis with morphological changess such as cell rounding and shrinkage with decreased cell number detachment and cytoplasmic condensation.

分子量

513.65

Formula

C₂₉H₃₁N₅O₂S

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.