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Antitumor agent-70
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Antitumor agent-70图片
CAS NO:2454133-88-9
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Antitumor agent-70 (化合物8b) 具有抗肿瘤活性,可以诱导细胞凋亡 (apoptosis)。Antitumor agent-70 抑制多发性骨髓瘤的IC50值为0.12 μM。Antitumor agent-70 是一种潜在的多靶点激酶抑制剂,尤其是对c-Kit
生物活性

Antitumor agent-70 (compound 8b) has anti-tumor activity and can induce cellapoptosis. Antitumor agent-70 inhibits multiple myeloma with anIC50value of 0.12 μM. Antitumor agent-70 is a potential multi-targeted kinase inhibitor especially forc-Kit[1].

体外研究
(In Vitro)

Antitumor agent-70 (compound 8b) (0-50 μM, 24 hours) has excellent anti-tumor proliferative activity, especially against multiple myeloma cell RPMI8226[1].
Antitumor agent-70 (compound 8b) (0-0.2 μM, 24 hours) arrests the cell cycle in G0/G1 phase[1].
Antitumor agent-70 (compound 8b) (0-0.2 μM, 24 hours) can induce apoptosis to inhibit cell proliferation by promoting ROS release cells[1].

Cell Proliferation Assay[1]

Cell Line:Human myeloma cell line U266, Human multiple myeloma cell line RPMI8226, Human umbilical vein endothelial cells HUVEC
Concentration:0-50 μM
Incubation Time:24 hours
Result:Showed anti-proliferative activity against U266, RPMI8226, HUVEC with an IC50value of 3.81 μM, 0.12 μM, 12.09 μM respectively.

Cell Cycle Analysis[1]

Cell Line:RPMI8226
Concentration:0-0.2 μM
Incubation Time:24 hours
Result:Showed a significant increase in the proportion of G0/G1 phase cells while S phase and G2/M phase decreased significantly.

Apoptosis Analysis[1]

Cell Line:RPMI8226
Concentration:0-0.2 μM
Incubation Time:24 hours
Result:Induced apoptosis rate increased with increasing concentration. Early apoptosis rate is higher than late apoptosis rate.
分子量

358.39

Formula

C21H18N4O2

CAS 号

2454133-88-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.