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Maprotiline
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Maprotiline图片
CAS NO:10262-69-8
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
马普替林
产品介绍
Maprotiline 是一种高选择性去甲肾上腺素再摄取 (noradrenergic reuptake) 阻滞剂,具有较强的抗抑郁效果。Maprotiline 通过靶向ERK信号通路和CRABP1诱导癌细胞凋亡 (apoptosis)。马普替林抑制细胞增殖和转移,具有抗癌作用。
生物活性

Maprotiline is a highly selectivenoradrenergic reuptakeblocker, has strongantidepressantefficacy. Maprotiline inducescancercellsapoptosisby targetingERKsignaling pathway andCRABP1. Maprotiline restrains cell proliferation and metastasis, exhibitsanticancereffect[1][2].

体外研究
(In Vitro)

Maprotiline (10 μM) enhances the sensitivity of HCC cells to sorafenib (2 μM) and induces apoptosis[2].
Maprotiline (0, 10, or 20 μM for 72 h) works on ERK pathway and inhibits phosphorylation of SREBP2 in HepG2 and Huh7 cells[2].
Maprotiline may target CRABP1 and regulate cholesterol biosynthesis in HCC cells[2].

Cell Invasion Assay[2]

Cell Line:The human HCC cell lines Huh7 and HepG2
Concentration:0, 10, 20 μM
Incubation Time:24 hours
Result:Restrained HCC cells migration with inhibition of epithelial-mesenchymal transition (EMT).

Cell Viability Assay[2]

Cell Line:The human HCC cell lines Huh7 and HepG2
Concentration:0, 10, 20 μM
Incubation Time:0, 24, 48, 72, 96, 120 hours
Result:Triggered cell apoptosis and inhibited the cell viability of Huh7 and HepG2 cells in a dose- and time-dependent manner.

Western Blot Analysis[2]

Cell Line:The human HCC cell lines Huh7 and HepG2
Concentration:0, 10, 20 μM
Incubation Time:72 hours
Result:Inhibited cholesterol biosynthesis in HCC Cells.
体内研究
(In Vivo)

Maprotiline (3, 10, or 30 mg/kg; i.p.) combinds with the synthetic cannabinoid WIN 55,212-2 and effectively reduces neuropathic pain[1].
Maprotiline (0, 20, or 40 mg/kg; i.p.; twice a week; 3 weeks) shows low toxicity and side effects on the organs, immune system and hematopoietic function[2].
Maprotiline (0, 20, or 40 mg/kg; i.p.; twice a week; 3 weeks) restrains cholesterol biosynthesis to inhibit growth and metastasis of HCC cells by interacting with CRABP1[2].

Animal Model:Male Balb-c mice (25–30 g)[1]
Dosage:3, 10, 30 mg/kg
Administration:Intraperitoneal injection; evaluation 30 minutes after treatment
Result:Attenuated pain-related behaviours in neuropathic mice.
Animal Model:Nude mice (BALB/C nu/nu, 4–6 weeks old, female)[2]
Dosage:40 mg/kg
Administration:Intraperitoneal injection; twice a week; 3 weeks
Result:Decreased the cholesterol levels in serum and tumors and suppressed the growth of Huh7-derived tumor xenografts without obvious toxic effect.
Clinical Trial
分子量

277.40

Formula

C20H23N

CAS 号

10262-69-8

中文名称

马普替林

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.