CAS NO: | 1818291-27-8 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | BI-0252 is an orally active, selectiveMDM2-p53inhibitor with anIC50of 4 nM. BI-0252 can induce tumor regressions in allanimalsof a mouse SJSA-1 xenograft, with concomitant induction of the tumor protein p53 (TP53) target genes and markers ofapoptosis[1]. | ||||||||||||||||
IC50& Target | IC50: 4 nM (MDM2-p53)[1] | ||||||||||||||||
体内研究 (In Vivo) | BI-0252 (orally; 25 mg/kg/day for 13 days and 100 mg/kg for 24 h) leads to time-dependent mRNA induction of TP53 target genes including CDKN1a, MDM2, and BBC3[1].
| ||||||||||||||||
分子量 | 566.45 | ||||||||||||||||
Formula | C30H26Cl2FN3O3 | ||||||||||||||||
CAS 号 | 1818291-27-8 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |