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Dihydroeponemycin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Dihydroeponemycin图片
CAS NO:126463-64-7
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Dihydroeponemycin, 是抗肿瘤和抗血管生成天然产物埃普霉素的类似物,选择性靶向 20S 蛋白酶体 (20S proteasome)。Dihydroeponemycin 共价修饰催化蛋白酶体亚单位的子集,优先与IFN-γ 诱导亚单位 LMP2 和 LMP7 结合Dihydroeponemycin 介导的蛋白酶体抑制诱导纺锤样细胞形态变化和细胞凋亡 (apoptosis)。
生物活性

Dihydroeponemycin, an analogue of the antitumor and antiangiogenic natural product eponemycin, selectively targets the20Sproteasome. Dihydroeponemycin covalently modifies a subset of catalytic proteasomal subunits, binding preferentially to the IFN-gamma-inducible subunits LMP2 and LMP7. Dihydroeponemycin-mediatedproteasomeinhibition induces a spindle-like cellular morphological change andapoptosis[1].

分子量

400.51

Formula

C20H36N2O6

CAS 号

126463-64-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.