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Tubulin inhibitor 11
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Tubulin inhibitor 11图片
CAS NO:2366260-33-3
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Tubulin inhibitor 11 是一种有效的具有口服活性的微管蛋白 (tubulin) 抑制剂。Tubulin inhibitor 11 靶向微管蛋白上的秋水仙碱结合位点,抑制微管蛋白聚合,促进有丝分裂阻断和细胞凋亡 (apoptosis)。
生物活性

Tubulin inhibitor 11 is a potent and orally activetubulininhibitor. Tubulin inhibitor 11 targets the Colchicine binding site on tubulin, inhibits tubulin polymerization, promotes mitotic blockade andapoptosis[1].

体外研究
(In Vitro)

Tubulin inhibitor 11 (Compound 48; 0.03-0.1 μM; 12 hours) causes cell cycle arrest at G2/M phase. Tubulin inhibitor 11 reduces cdc2 phosphorylation and increases cyclin B1 and phosphorylation of histone H3 at Ser10 in cells[1].
Tubulin inhibitor 11 (Compound 48; 0.03-0.3 μM; 48 hours) causes cancer cell apoptosis[1].
Tubulin inhibitor 11 (Compound 48) demonstrates favorable antiproliferative activities in DU145 cells with an IC50of 8 nM[1].
Tubulin inhibitor 11 (Compound 48; 0.03-0.3 μM) significantly reduces the expression levels of acetyl-α-tubulin and α-tubulin in a dose-dependent manner[1].

Cell Cycle Analysis[1]

Cell Line:DU145 cells
Concentration:0.01 μM, 0.03 μM, and 0.1 μM
Incubation Time:12 hours
Result:Caused cell cycle arrest at G2/M phase.

Apoptosis Analysis[1]

Cell Line:DU145 cells
Concentration:0.03 μM, 0.1 μM, and 0.3 μM
Incubation Time:48 hours
Result:Induced cancer cell apoptosis.

Western Blot Analysis[1]

Cell Line:DU145 cells
Concentration:0.01 μM, 0.03 μM, and 0.1 μM
Incubation Time:12 hours
Result:Reduced cdc2 phosphorylation and increased cyclin B1 and phosphorylation of histone H3 at Ser10 in cells.
体内研究
(In Vivo)

Tubulin inhibitor 11 (Compound 48; 5-10 mg/kg; p.o; once daily) shows robust in vivo antitumor efficacies[1].

Animal Model:Male athymic BALB/c nude mice (18-20 g) injected with DU145, NCI-H1299 or A549R cells[1]
Dosage:5 mg/kg, 10 mg/kg
Administration:p.o; once daily
Result:Effectively suppressed tumor growth.
分子量

409.50

Formula

C22H23N3O3S

CAS 号

2366260-33-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.