CAS NO: | 926661-54-3 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | CRTH2-IN-1 (Ramatroban analog) is a selectiveprostaglandin D2 receptor DP2(CRTH2) antagonist with an IC50of 6 nM in a human DP2 binding assay. | ||
IC50& Target |
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体外研究 (In Vitro) | CRTH2-IN-1 (Ramatroban analog, Compound 5) is a novel prostaglandin D2 receptor DP2 (CRTH2) antagonist with an IC50of 7 nM in a human whole blood eosinophil shape change assay (hESC). CRTH2-IN-1 (Ramatroban analog) is a novel tricyclic antagonist of the prostaglandin D2 receptor DP2 (CRTH2) with efficacy in a murine model of allergic rhinitis. Human prostaglandin D1 receptor (hDP1) binding is performed using3H-PGD2 and human platelet membranes. Human thromboxane receptor (hTP) binding performed using human platelet membranes and3H-SQ-29,548. Human prostacyclin receptor (hIP) binding perfomed using hIP/293 membranes and3Hiloprost. CRTH2-IN-1 inhibits hDP1 binding with an IC50of 1μM. CRTH2-IN-1 inhibits hTP and hIP binding with IC50s of >100 μM. CRTH2-IN-1 inhibits human CYP isoforms CYP3A4, CYP 2C9 and CYP2D6 with IC50s of 7, 5 and >30 μM, respectively[1]. | ||
分子量 | 416.47 | ||
Formula | C21H21FN2O4S | ||
CAS 号 | 926661-54-3 | ||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |