CAS NO: | 1027847-67-1 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | AMG-009 is a potent antagonist ofprostaglandin D2, withIC50of 3 nM and 12 nM for CRTH2 andDPreceptors, respectively. | |
IC50& Target[3] |
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体外研究 (In Vitro) | AMG-009 inhibits PGD2-induced down-modulation of CRTH2 on CD16 negative granulocytes (eosinophils) in human whole blood with a Kiof 1 nM. AMG 009 also inhibits PGD2-induced cAMP response mediated by DP in platelets in 80% human whole blood with a Kiof 148 nM. AMG 009 inhibits guinea pig CRTH2 receptors (IC50=3 nM) and a PGD2-induced cAMP response assay with cells expressing the guinea pig DP receptors (Ki=131 nM)[1]. | |
体内研究 (In Vivo) | AMG 009 (3, 10 or 30 mg/kg, s.c.) results in a dose dependent decrease in airway resistance provoked by PGD2 aerosol in an acute guinea pig model[1]. In a guinea pig model of PGD2-induced airway constriction, AMG 009 significantly improves DP potency, with Kbof 82 nM[2]. | |
分子量 | 581.46 | |
Formula | C26H26Cl2N2O7S | |
CAS 号 | 1027847-67-1 | |
运输条件 | Room temperature in continental US; may vary elsewhere. | |
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |