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AMG-009
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
AMG-009图片
CAS NO:1027847-67-1
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
AMG-009 是prostaglandin D2的有效拮抗剂,对 CRTH2 和 DP 受体的IC50值分别为 3 nM 和 12 nM。
生物活性

AMG-009 is a potent antagonist ofprostaglandin D2, withIC50of 3 nM and 12 nM for CRTH2 andDPreceptors, respectively.

IC50& Target[3]

DP

3 nM (IC50)

体外研究
(In Vitro)

AMG-009 inhibits PGD2-induced down-modulation of CRTH2 on CD16 negative granulocytes (eosinophils) in human whole blood with a Kiof 1 nM. AMG 009 also inhibits PGD2-induced cAMP response mediated by DP in platelets in 80% human whole blood with a Kiof 148 nM. AMG 009 inhibits guinea pig CRTH2 receptors (IC50=3 nM) and a PGD2-induced cAMP response assay with cells expressing the guinea pig DP receptors (Ki=131 nM)[1].

体内研究
(In Vivo)

AMG 009 (3, 10 or 30 mg/kg, s.c.) results in a dose dependent decrease in airway resistance provoked by PGD2 aerosol in an acute guinea pig model[1]. In a guinea pig model of PGD2-induced airway constriction, AMG 009 significantly improves DP potency, with Kbof 82 nM[2].

分子量

581.46

Formula

C26H26Cl2N2O7S

CAS 号

1027847-67-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.