CAY10580

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CAY10580

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:	64054-40-6
包装:	1mg (14.64 mM * 200 uL in ethanol)
市场价:	5400元

产品介绍

CAY10580是有效和选择性的前列腺素EP4受体 (EP₄) 激动剂 (K_i=35 nM)。

生物活性

CAY10580 is a potent and selective prostaglandinEP₄receptoragonist (K_i=35 nM)^[1].

IC₅₀& Target^[1]

EP4

35 nM (Ki)

EP2

3000 nM (Ki)

EP3

2000 nM (Ki)

EP1

>3000 nM (Ki)

体外研究
(In Vitro)

CAY10580 (10-10000 nM; 40 min) significantly increases apical membrane abundance of AQP2 in MDCK cells at 100 to 10000 nM^[2].

体内研究
(In Vivo)

CAY10580 (200 μg/kg body weight; i.p; daily for three weeks) effectively prevents diet-induced hypercholesterolemia, enhances endogenous bile acid synthesis and their fecal excretion^[3].

Animal Model:	Six-week old male EP4^+/+mice (Treating high fat diet-challenged mice)^[3]
Dosage:	200 μg/kg body weight
Administration:	Intraperitoneal injection; daily for remaining three weeks
Result:	High fat diet fed mice exhibited lower total cholesterol levels compared to the vehicle group by 28.5%. Total cholesterol levels decreased from 137.4 to 98.2 mg/dl, restoring plasma cholesterol back to near-normal values.

分子量

341.49

性状

Liquid

Formula

C₁₉H₃₅NO₄

CAS 号

64054-40-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Solution, -20°C, 2 years