(S)-Remoxipride

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(S)-Remoxipride

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

80125-14-0

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品名称

(-)-Remoxipride

产品介绍

(S)-Remoxipride ((-)-Remoxipride) 是选择性的多巴胺D₂-receptor拮抗剂，IC₅₀值为 1.57 μM。(S)-Remoxipride 可以用于精神障碍的研究。

生物活性

(S)-Remoxipride ((-)-Remoxipride) is a selective dopamineD₂-receptorantagonist with anIC₅₀value of 1.57 μM. (S)-Remoxipride can be used for the research of psychotic disorder^[1].

IC₅₀& Target

D₂Receptor

1.57 μM (IC₅₀)

D₁Receptor

＞100 μM (IC₅₀)

α₁-Adrenoccptor

42 μM (IC₅₀)

体外研究
(In Vitro)

(S)-Remoxipride (1-100 μM; 20 min) shows binding efficiency with IC₅₀s of ＞100, 1.57 and 42 μM for dopamine D₁, dopamine D₂and α₁-Adrenoccptor, respectively^[1].

体内研究
(In Vivo)

(S)-Remoxipride (0.1-100 μM/kg; i.p. 60 min prior to apomorphine) blockades apomorphine-induced behaviors s in rats and vomiting in dogs^[1].
(S)-Remoxipride (0.1-10 mg/kg; i.p. 30 min prior to apomorphine) displaces [³H]spiperone from both striatal and extra-striatal areas^[1].

Animal Model:	Male Sprague-Dawley rats^[1]
Dosage:	0.1-100 μM/kg
Administration:	Intraperitoneal injection; 0.1-100 μM/kg; 60 min prior to apomorphine
Result:	Blocked apomorphine-induced hyperactivity and dose-dependent blockaded apomorphine-induced behaviors in vivo.

Animal Model:	Male and female beagle dogs^[1]
Dosage:	0.25-5 μM/kg
Administration:	Oral gavage; 0.25-5 μM/kg; 60 min prior to apomorphine
Result:	Blocked apomorphine-induced vomiting in dogs.

分子量

371.27

Formula

C₁₆H₂₃BrN₂O₃

CAS 号

80125-14-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.