Amphomycin is alipopeptideantibiotic that inhibits peptidoglycan synthesis and blocks cell wall development. Amphomycin exhibits potent antibacterial activities against methicillin-resistantS. aureus(MRSA), vancomycin-resistant enterococci (VRE), penicillin-gentamicin-erythromycin-resistantS. pneumonia, and linezolid-quinupristin-dalfopristin-resistant enterococci^[1][2][3].

Amphomycin (40 μ g/mL; 60 min) leadsS. aureusto exhibit cell wall thinning and Park’s nucleotide accumulation^[1].

Amphomycin (50 mg/kg; p.o.; single) shows low oral availability and (5-10mg/kg; i.v.; single) exhibits a long half-life (5.2-8.0 h in mice and 4.6-7.1 h in rats)^[2].

1402-82-0

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