Tiprelestat

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Tiprelestat

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

820211-82-3

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

Tiprelestat 是一种有效的人类中性粒细胞弹性蛋白酶 (elastase) 抑制剂。Tiprelestat 具有抗菌和抗炎活性。Tiprelestat 可用于炎症/免疫疾病的研究。

生物活性

Tiprelestat is a potent human neutrophilelastaseinhibitor. Tiprelestat has antimicrobial and anti-inflammatory activities. Tiprelestat can be used in the research of inflammation/immune disease^[1].

体外研究
(In Vitro)

Tiprelestat (4 and 8 μM) inhibitsP. aeruginosa-secreted peptidase^[3].
Tiprelestat (10 μg/mL, 1 h) inhibits LPS-induced MCP-1 production in U937 cells^[4].
Tiprelestat (10 μg/mL, 1 h) down-regulates LPS-induced AP-1 and NF-κB activation in U937 cells^[4].

Western Blot Analysis^[4]

Cell Line:	U937 cells
Concentration:	10 μg/mL
Incubation Time:	1 h
Result:	Prevented LPS-induced degradation of IκBα, IκBβ, and IRAK.

体内研究
(In Vivo)

Tiprelestat (1 mg/kg, intranasal inhalation) suppresses lung elastase activity and apoptosis in MV-O₂mice^[2].
Tiprelestat (0.2 mg/kg, s.c. for 2 weeks) attenuates hypoxic pulmonary hypertension in mice^[5].

Animal Model:	Mice, treated with Mechanical ventilation with O₂-rich gas^[2]
Dosage:	1 mg/kg
Administration:	Intranasal inhalation
Result:	Increased the lung abundance of nuclear Klf4 protein.

Animal Model:	Su/Hx rat model^[5]
Dosage:	0.2 mg/kg
Administration:	Subcutaneous injection (s.c.), daily for 2 weeks.
Result:	Reduced elastase activity and reversed pulmonary hypertension.

Clinical Trial

分子量

5999.09

Formula

C₂₅₄H₄₁₆N₇₂O₇₅S₁₀

CAS 号

820211-82-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.