Hispolon 是一种多酚，可从桑黄 (Phellinus linteus) 中分离得到。Hispolon 具有抗癌、抗糖尿病、抗氧化、抗病毒、肝保护活性、抗糖尿病和抗炎活性。
| 生物活性 | Hispolon, a polyphenol, can be isolated fromPhellinus linteus. Hispolon possesses anticancer, antidiabetic, antioxidant, antiviral, hepatoprotective, anti-diabetic, and anti-inflammatory activities[1]. |
体外研究
(In Vitro) | Hispolon (25 and 50 μM, 24-72 h) inhibits cell viability of U87MG cells[2].
Hispolon (25 and 50 μM, 24, 48 h) induces G2/M cell cycle arrest and apoptosis in U87MG cells[2].
Hispolon (25 and 50 μM, 2-8 h) decreases the expression of G1–S transition-related protein cyclin D4 but increases the expression of CDK inhibitor p21[2].
Hispolon (25 and 50 μM, 24 h) inhibits the migration of U87MG cells[2].
Cell Viability Assay[2] | Cell Line: | U87MG cells | | Concentration: | 25 and 50 μM | | Incubation Time: | 24, 48, 72 h | | Result: | Inhibited cell viability in a dose and time dependent way. |
Western Blot Analysis[2] | Cell Line: | U87MG cells | | Concentration: | 25 and 50 μM | | Incubation Time: | 2, 4, 8 h | | Result: | Decreased cyclin D4 level, and increased p21 level. |
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体内研究
(In Vivo) | Hispolon (2.5-10 mg/kg, i.p.) attenuates LPS-induced acute lung injury in mice[3].
Hispolon (5 and 10 mg/kg, s.c.) reduces tumor growth in DBTRG xenograft mice[4].
| Animal Model: | LPS-induced acute lung injury mice[3] | | Dosage: | 2.5, 5 and 10 mg/kg | | Administration: | Intraperitoneal injection (i.p.) | | Result: | Alleviated the pathological effects in the LPS-challenged mouse.
Reduced the W/D ratio in the lung and MPO activity.
Decreased pro-Inflammatory cytokine production. |
| Animal Model: | DBTRG xenograft mice[4] | | Dosage: | 5 and 10 mg/kg | | Administration: | Subcutaneous injection (s.c.) | | Result: | Reduced tumor volume (RTV).
Inhibited GBM cell proliferationin vivoupon HE and ki-67 staining. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | 4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
| 溶解性数据 | In Vitro: DMSO : 125 mg/mL(567.61 mM;ultrasonic and warming and heat to 70℃) 配制储备液 | 1 mM | 4.5409 mL | 22.7046 mL | 45.4091 mL | | 5 mM | 0.9082 mL | 4.5409 mL | 9.0818 mL | | 10 mM | 0.4541 mL | 2.2705 mL | 4.5409 mL |
*请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (protect from light)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。 |
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