Maresin 1

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Maresin 1

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:	1268720-28-0
包装:	25 μg (277.4 μM * 250 μL in Ethanol)
市场价:	6150元

产品介绍

Maresin 1 是人体内源性的 DHA 产生的特异性调节介质，可以刺激胞内Ca²⁺产生和分泌。Maresin 1 具有抗炎活性。

生物活性

Maresin 1, produced by human Mφs from endogenous docosahexaenoic acid (DHA) and a specialized proresolving mediator, stimulates intracellular [Ca²⁺] and secretion. Maresin 1 possesses anti-inflammatory activity^[1]^[2]^[3].

体外研究
(In Vitro)

Maresin 1 (MaR1, 300 nM) reduces neutrophil migration and reactive oxygen species production, besides decreasing IL-1b, TNF-a, IL-6, and INF-g production^[3].

Cell Viability Assay^[3]

Cell Line:	Neutrophils (2 ╳10⁵cells/well).
Concentration:	300 nM.
Incubation Time:	30 min.
Result:	Adherent cells are stimulated for 24 h with LPS (1 mg/ml) in the presence or absence of MaR1 (300 nM) in a final volume of 250 ml/well^[3].

体内研究
(In Vivo)

Maresin 1 (MaR1) dose-dependently inhibits TRPV1 currents in neurons, blocks capsaicin (100 nM)-induced inward currents (IC₅₀=0.49 nM), and reduces both inflammation- and chemotherapy-induced neuropathic pain in mice^[2].
Maresin 1 (MaR1, 0.1, 0.3, and 1 μg/animal, e.v.) protects mice against acute DSS-induced colitis. Maresin 1 (0.3, and 1 μg/animal, e.v.) treatment markedly reduces macroscopic damage in the acute protocol of DSS-induced colitis^[3].

Animal Model:	Male CD1 mice (8-10 wk of age) (colitis was induced by DSS)^[3].
Dosage:	0.1, 0.3, and 1 μg/animal.
Administration:	Intraocular route once a day from day 0 to day 7.
Result:	MaR1 (0.3 and 1 mg/animal) significantly reduces MPO levels in mouse colon tissue.

分子量

360.49

性状

Liquid

Formula

C₂₂H₃₂O₄

CAS 号

1268720-28-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Solution, -20°C, 2 years