8A8 is a potent proinflammatory factorNOinhibitor with anIC₅₀of 4.7 μM. 8A8 also significantly inhibits LPS-induced HaCat cell proliferation^[1].

Low concentrations of compound 8A8 (2.5 μM; RAW 264.7 cells) could significantly down-regulate IL-6 and TNF-α in cellular emotional intelligence, IL-6 and TNF-α are only half of those after LPS treatment at 5 μM, and IL-6 and TNF-α in cell supernatants were only a quarter of those after LPS treatment after high concentration compound 8A8 (10 μM)^[1].

799.06

C₃₆H₃₇BrClN₅O₉

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.