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Neutrophil Elastase Inhibitor
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Neutrophil Elastase Inhibitor图片
CAS NO:1448314-31-5
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍

neutrophil elastase inhibitor

Cas No.1448314-31-5
化学名1-(3-methylbenzoyl)-1H-indazole-3-carbonitrile
Canonical SMILESO=C(C1=CC=CC(C)=C1)N2C3=CC=CC=C3C(C#N)=N2
分子式C16H11N3O
分子量261.3
溶解度≤0.5mg/ml in ethanol;10mg/ml in DMSO;30mg/ml in dimethyl formamide
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
文献引用
产品描述

IC50: 7 nM

Neutrophil Elastase Inhibitor is a neutrophil elastase inhibitor.

Human neutrophil elastase (HNE) is a member of the chymotrypsin superfamily of serine proteases that is involved in the response to inflammatory stimuli. HNE is reported to be stored in azurophilic granules of neutrophils and is greatly aggressive and cytotoxic, as its substrates include various components of the extracellular matrix.

In vitro: Previous study found that Neutrophil Elastase Inhibitor was able to inhibit thrombin and urokinase at micromolar concentrations. In addition, Neutrophil Elastase Inhibitor appeared to be a specific HNE inhibitors in a competitive manner. Moreoer, the hydrolysis of the acyl-enzyme complex for Neutrophil Elastase Inhibitor was found to be much slower than spontaneous hydrolysis of Neutrophil Elastase Inhibitor, and HNE was observed to be still inhibited to 80% of control level at 7 h after treatment [1].

In vivo: So far, there is no animal in vivo data reported.

Clinical trial: Up to now, Neutrophil Elastase Inhibitor is still in the preclinical development stage.

References:
[1] L. Crocetti, I. A. Schepetkin, A. Cilibrizzi, et al. Optimization of N-benzoylindazole derivatives as inhibitors of human neutrophil elastase. Journal of Medicinal Chemistry 56(15), 6259-6272 (2013).