TP-238 is a potent and selective dualCECR2/BPTFprobe withIC₅₀values of 30 nM and 350 nM, respectively. TP-238 also inhibitsBRD9with apIC₅₀of 5.9 and is less active against other 338 kinases^[1][2].

TP-238 has on target biochemical activity of 10-30 nM with CECR2 and 100-350 nM with BPTF. TP-238 displays potency for both CECR2 (pIC50 of 7.5) and BPTF (pIC50 of 6.5) in an Alpha screen assay. Isothermal titration calorimetry (ITC) shows TP-238 with a Kd of 10 nM for CECR2 and 120 nM for BPTF^[1][2].

458.58

C₂₂H₃₀N₆O₃S

2415263-04-4

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.