Dithiodipropionic acid can interact withCPUL1(HY-151802, aTrxRinhibitor) to form nanoaggregates (CPUL1-DA NAs). CPUL1-DA NAs generates more abundantROSto induce cellapoptosisthan that of free CPUL1, and improves antitumor efficacy against HUH7cancercells^[1].

CPUL1-DA NAs (molar ratio was 1:2) inhibits HUH7 hepatoma cell viability with an IC₅₀value of 4.3 μM, and has weak cytotoxicity against normal L02 cells^[1].
CPUL1-DA NAs (2.5-10 μM, 6 h) can be more effectively enriched in HUH7 cells mitochondria and displays faster cellular uptake ability to deliver CPUL1 into cells than that of free CPUL1^[1].
CPUL1-DA NAs (2.5-10 μM, 12 h) results in the accumulation of superoxides and mitochondrial membrane damage in HUH7 cells^[1].

210.26

Solid

C₆H₁₀O₄S₂

1119-62-6

3,3'-二硫代二丙酸

Room temperature in continental US; may vary elsewhere.