Orphenadrine hydrochloride

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

341-69-5

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品名称

盐酸奥芬那君；盐酸邻甲苯海拉明；奥芬那君盐酸盐

产品介绍

Orphenadrine hydrochloride 是一种口服有效的非竞争性NMDA受体拮抗剂 (可透过血脑屏障)，其K_i值为 6.0 μM。Orphenadrine hydrochloride 能缓解因肌肉拉伤、扭伤或其他损伤引起的僵硬、疼痛和不适，也用于缓解帕金森病引起的颤抖。Orphenadrine hydrochloride 具有较好的神经保护作用，可用于神经退行性疾病的研究。

生物活性

Orphenadrine hydrochloride is an orally active and non-competitiveNMDA receptorantagonist (crosses the blood-brain barrier) with aK_iof 6.0 μM. Orphenadrine hydrochloride relieves stiffness, pain and discomfort due to muscle strains, sprains or other injuries. Orphenadrine hydrochloride is also used to relieve tremors associated with parkinson's disease. Orphenadrine citrate has good neuroprotective properties, can be used in studies of neurodegenerative diseases^[1]^[2].

体外研究
(In Vitro)

Orphenadrine hydrochloride (12 μM; 24.5 h) shows neuroprotective effects on 3-NPA-induced neurotoxicity cerebellar granule cells^[1].

Cell Viability Assay^[1]

Cell Line:	CGC cells (7-day-old Sprague Dawley rat)
Concentration:	6, 12, 24, 48 μM
Incubation Time:	24.5 h
Result:	Prevented cells from 3-NPA induced cellular aggregation,volume diminution and neurite fragmentation.

体内研究
(In Vivo)

Orphenadrine hydrochloride (10, 20, 30 mg/kg; i.p.; once aday for 3 days) reduces 3-NPA-induced mortality in a dose-dependent manner^[1].
Orphenadrine hydrochloride (30 mg/kg; i.p.; once aday for 3 days) shows activity to against 3-NPA-induced neuronal damage in vivo^[1].

Animal Model:	Adult male Sprague Dawley rats (275-300 g; 3-NPA toxicity model)^[1].
Dosage:	10, 20, 30 mg/kg
Administration:	Intraperitoneal injection; once aday for 3 days (30 min before 3-NPA)
Result:	Reduced mortality of 3-NPA toxicity rats to 10-40% (3-NPA-treated animals showed general incoordination, drowsiness and general weakness). Recovered 3-NPA-induced body weight loss, and when at 30 mg/kg reduced the level of PBR and expression of HSP27. (PBR and HSP27 are markers of neuronal damage).

Clinical Trial

分子量

305.84

Formula

C₁₈H₂₄ClNO

CAS 号

341-69-5

中文名称

盐酸奥芬那君；盐酸邻甲苯海拉明；奥芬那君盐酸盐

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.