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α-Cyperone
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
α-Cyperone图片
CAS NO:473-08-5
包装:20mg
市场价:1386元

产品介绍
α-Cyperone (α-Cyperone) 与 COX-2、IL-6、Nck-2、Cdc42 和 Rac1 的下调有关，从而减少炎症，这将非常有利于炎症性疾病的治疗比如AD。
Cas No.473-08-5
别名alpha-香附酮,α-Cyperone; (+)-α-Cyperone
化学名(4aS,7R)-1,4a-dimethyl-7-prop-1-en-2-yl-3,4,5,6,7,8-hexahydronaphthalen-2-one
Canonical SMILESCC1=C2CC(CCC2(CCC1=O)C)C(=C)C
分子式C15H22O
分子量218.33
溶解度≥ 21.8mg/mL in DMSO
储存条件Store at -20°C,unstable in solution, ready to use.
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

alpha-Cyperone (α-Cyperone) is associated with the down-regulation of COX-2, IL-6, Nck-2, Cdc42 and Rac1, resulting in reduction of inflammation, which would be highly beneficial for treatment of inflammatory diseases such as AD.

The anti-inflammatory activity of alpha-Cyperone (α-Cyperone) is associated with the down-regulation of COX-2 and IL-6 via the negative regulation of the NFκB pathway in LPS-stimulated RAW 264.7 cells[1].alpha-Cyperone (α-Cyperone) binds and interacts with tubulin and is capable of distinctly destabilizing microtubule polymerization. The effect of this interaction could result in reduction of inflammation which would be highly beneficial for treatment of inflammatory diseases such as AD. One microliter of alpha-Cyperone was dissolved in DMSO (1:1 v/v) and it was further diluted in double distilled water (ddH2O) to a final volume of 20 microliter[2].

References:
[1]. Jung, S. H. et al. alpha-Cyperone, isolated from the rhizomes of Cyperus rotundus, inhibits LPS-induced COX-2 expression and PGE2 production through the negative regulation of NFkappaB signalling in RAW 264.7 cells. Journal of ethnopharmacology 147, 208-214, doi:10.1016/j.jep.2013.02.034 (2013).
[2]. Azimi, A. et al. alpha-Cyperone of Cyperus rotundus is an effective candidate for reduction of inflammation by destabilization of microtubule fibers in brain. Journal of ethnopharmacology, doi:10.1016/j.jep.2016.06.058 (2016).