LY5

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LY5

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1436382-03-4

包装与价格：

包装	价格(元)
5mg	电议
10mg	电议
25mg	电议
50mg	电议

产品介绍

LY5 是STAT3的抑制剂，IC₅₀值为 0.5 μM。LY5 诱导细胞凋亡并抑制 STAT3 磷酸化。LY5 具有体内抗肿瘤活性，可用于癌症的研究。

生物活性

LY5 is aSTAT3inhibitor with anIC₅₀value of 0.5 μM. LY5 inducesapoptosisand inhibitsSTAT3phosphorylation. LY5 shows antitumor activity in vivo, it can be used for the research ofcancer^[1].

IC₅₀& Target

IC50: 0.5 μM (STAT3)^[1]

体外研究
(In Vitro)

LY5 shows inhibition effects to U2OS, RH30 and RD2 cancer cells with IC₅₀values of 0.52, 0.55 and 1.39 μM, respectively^[1].
LY5 (0.25-1 μM; 16 h) induces apoptosis and inhibits STAT3 phosphorylation in human sarcoma cancer cells^[1].
LY5 (0.25-1 μM; 5 h) inhibits STAT3 phosphorylation induced by IL-6^[1].

Western Blot Analysis^[1]

Cell Line:	RH30 and EW8 cell lines
Concentration:	0.25-1 μM
Incubation Time:	16 hours
Result:	Completely inhibited Tyr705 phosphorylation at 0.5 μM and dose-dependently decreased in formation of P-STAT3.

体内研究
(In Vivo)

LY5 (5 mg/kg; i.p. once daily for 21 days) inhibits breast tumor growth in vivo^[1].

Animal Model:	Nude mice with MDA-MB-231 cancer cells injection^[1]
Dosage:	5 mg/kg
Administration:	Intraperitoneal injection; 5 mg/kg; once daily; for 21 days
Result:	Suppressed tumor growth and significantly reduced the tumor sizes.

分子量

329.33

Formula

C₁₅H₁₁N₃O₄S

CAS 号

1436382-03-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.