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Melitracen
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Melitracen图片
CAS NO:5118-29-6
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
Melitracene
N 7001
Trausabun
产品介绍
Melitracen (Melitracene) 是一种具有口服活性的三环抗抑郁药,也是一种具有激活特性的躁狂症药物。Melitracen 对3H-5-HT 和14H-5-HT 具有抑制作用,其IC50值分别为 670 nM 和 5500 nM。Melitracen 可用于抑郁和焦虑的研究。
生物活性

Melitracen (Melitracene) is an orally activetricyclic antidepressantand it is also a bipolar thymoleptic with activating properties. Melitracen inhibits3H-5-HT and14H-5-HT withIC50s of 670 nM and 5500 nM, respectively. Melitracen can be used for the research of depression and anxiety[1][2].

IC50& Target

IC50: 670 nM (3H-5-HT), 5500 nM (14H-5-HT)[2]

体外研究
(In Vitro)

Melitracen (0-10 μM; 10 min) inhibits3H-5-HT in synaptosomes and14H-5-HT in blood platelets[2].

Cell Viability Assay[2]

Cell Line:Synaptosomes and blood platelets from male albino rats
Concentration:0-10 μM
Incubation Time:10 min
Result:Inhibited3H-5-HT in synaptosomes and14H-5-HT in blood platelets with IC50s of 670 nM and 5500 nM, respectively.
体内研究
(In Vivo)

Melitracen (10-90 mg/kg; p.o. once daily for 3 months) affects behavior, weight and growth of rats[1].

Animal Model:Male and female Wistar rats[1]
Dosage:10, 30 and 90 mg/kg
Administration:Oral gavage; 10-90 mg/kg daily; for 3 months
Result:Showed aggressive behaviour, excitability, body and livers weight gain, and livers slight atrophic with increasing dose to rats.
Clinical Trial
分子量

291.43

Formula

C21H25N

CAS 号

5118-29-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.