Cyclo(Arg-Gly-Asp-D-Phe-Val)

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

137813-35-5

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

Cyclo(Arg-Gly-Asp-D-Phe-Val) 是一种整合素αvβ3抑制剂。Cyclo(Arg-Gly-Asp-D-Phe-Val) 具有抗肿瘤活性。Cyclo(Arg-Gly-Asp-D-Phe-Val) 可用于急性髓系白血病的研究。

生物活性

Cyclo(Arg-Gly-Asp-D-Phe-Val) is anintegrinαvβ3inhibitor. Cyclo(Arg-Gly-Asp-D-Phe-Val) has antitumor activity. Cyclo(Arg-Gly-Asp-D-Phe-Val) can be used for the research of acute myeloid leukemia^[1].

IC₅₀& Target

αvβ3^[1]

体外研究
(In Vitro)

Cyclo(Arg-Gly-Asp-d-Phe-Val) (c(RGDfV)) (35 nM, 4-24 h) disruptes the adhesion and migration between the tumor cells and the matrix, induces the leukemia cells to leave the protective microenvironment and increases their sensitivity to cell cycle-dependent agents^[1].

Cell Cycle Analysis^[1]

Cell Line:	MV4–11 cells
Concentration:	35 nM
Incubation Time:	24 h
Result:	Affected the leukemia cell cycle, decreased the G0/G1 phase of leukemia cells in the 3D and 2D culture systems and increased the S phase of leukemia cells in the 3D and 2D culture systems.

Apoptosis Analysis^[1]

Cell Line:	MV4–11 cells
Concentration:	35 nM
Incubation Time:	24 h
Result:	Increased the apoptosis rates.

分子量

574.63

Formula

C₂₆H₃₈N₈O₇

CAS 号

137813-35-5

Sequence Shortening

Cyclo(RGD-{d-Phe}-V)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.