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Ezutromid
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Ezutromid图片
CAS NO:945531-77-1
包装与价格:
包装价格(元)
10 mM * 1 mL in DMSO电议
5mg电议
10mg电议
50mg电议
100mg电议
200mg电议
500mg电议

产品名称
SMT C1100
BMN 195
VOX-C1100
产品介绍
Ezutromid (SMT C1100) 是一种首创的,具有口服活性的苯并恶唑utrophin调节剂,EC50为 0.91 μM。Ezutromid 可用于 Duchenne 型肌营养不良症 (DMD) 的研究。Ezutromid 抑制人肝微粒体 CYP1A2 酶活性,IC50为 5.4 μM。
生物活性

Ezutromid (SMT C1100) is a first-in-class, orally active benzoxazoleutrophinmodulator with anEC50of 0.91 μM. Ezutromid can be used for the research Duchenne muscular dystrophy (DMD). Ezutromid inhibits CYP1A2 enzymic activity in human liver microsomes (HLM) with an IC50of 5.4 μM[1][2].

IC50& Target

CYP1

 

体外研究
(In Vitro)

Ezutromid induces increased levels of utrophin RNA in human muscle cells. Treatment of human DMD cells with Ezutromid lead to a 2-fold increase in utrophin protein levels at an optimal concentration of 0.3 uM after 3 days of treatment. Ezutromid was safe and well tolerated with plasma concentrations achieved suf cient to cause a 50% increase in concentrations of utrophin in cells. Ezutromid led to a 30% increase in Utrn mRNA level and resulted in a 2.0-fold increase in UTRN protein level[3][4][5].

体内研究
(In Vivo)

Note: You can dissolve the products in phosphate buffered saline (PBS), 0.1% Tween-20, 5% DMSO)

Clinical Trial
分子量

337.39

性状

Solid

Formula

C19H15NO3S

CAS 号

945531-77-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month
溶解性数据
In Vitro: 

DMSO : 10 mg/mL(29.64 mM;Need ultrasonic and warming)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM2.9639 mL14.8196 mL29.6393 mL
5 mM0.5928 mL2.9639 mL5.9279 mL
10 mM0.2964 mL1.4820 mL2.9639 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。