Azelastine

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Azelastine

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

58581-89-8

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品名称

氮卓斯汀

产品介绍

Azelastine 属于抗组胺剂，是一种有效的选择性组胺 1 (H₁) 拮抗剂。Azelastine 可用于过敏性鼻炎、哮喘、糖尿病高脂血症和 SARS-CoV-2 的研究。

生物活性

Azelastine, an antihistamine, is a potent and selectivehistamine 1 (H₁)antagonist. Azelastine can be used for the research of allergic rhinitis, asthma, diabetic hyperlipidemic and SARS-CoV-2^[1]^[2]^[3]^[4].

IC₅₀& Target^[1]

H₁Receptor

体外研究
(In Vitro)

Azelastine can significantly inhibit HNEpC proliferation, and therefore, be helpful in against airway remodeling^[5].

Cell Proliferation Assay^[5]

Cell Line:	Human nasal epithelial cells (HNEpC)
Concentration:	100 μM, 400 μM
Incubation Time:	21 days
Result:	Inhibited HNEpC growth.

Western Blot Analysis^[5]

Cell Line:	Human nasal epithelial cells (HNEpC)
Concentration:	100 μM
Incubation Time:	7 days
Result:	Significantly up-regulated the H1R, M1R and M3R levels.

体内研究
(In Vivo)

Azelastine (4 mg/kg; p.o.; daily; for 8 weeks) significantly reduces blood glucose, HbA1c and serum alkaline phosphatase (ALP), osteocalcin and downregulates apolipoprotein B in diabetic hyperlipidemic rats model^[2].
Azelastine (4 mg/kg; p.o.; daily; for 8 weeks) improves the lipid profile (LDL-c decrease and HDL-c increase) in diabetic hyperlipidemic rats model^[2].
Azelastine (4 mg/kg; p.o.; daily; for 8 weeks) attenuates calcium deposition and aortic calcification in diabetic hyperlipidemic rats model^[2].

Animal Model:	Male albino Wistar rats (150-170 g), diabetic hyperlipidemic rats model^[2]
Dosage:	4 mg/kg
Administration:	Oral administration, daily, for 8 weeks
Result:	Ameliorated aortic calcification and increased apolipoprotein A expression along with a decline in apolipoprotein B.

Clinical Trial

分子量

381.90

Formula

C₂₂H₂₄ClN₃O

CAS 号

58581-89-8

中文名称

氮卓斯汀

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.