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Xanthohumol D
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Xanthohumol D图片
CAS NO:274675-25-1
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
Xanthohumol D,分离于酒花,是一种醌还原酶2 (QR-2) 抑制剂,IC50 为110 μM,并与 QR-2 活性位点结合。Xanthohumol D 在体外对人癌细胞株有抗增殖作用。
Cas No.274675-25-1
Canonical SMILESO=C(C1=C(OC)C=C(O)C(CC(O)C(C)=C)=C1O)/C=C/C2=CC=C(O)C=C2
分子式C21H22O6
分子量370.4
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Xanthohumol D, isolated from hops, is an inhibitor of quinone reductase-2 (QR-2) with the IC50 value of 110 μM, and binds to the active site of QR-2. Xanthohumol D shows antiproliferative activity on human cancer cell lines in vitro[1][2]. IC50: 110 μM (Quinone reductase-2)[1]

[1]. Choi Y, et al. Screening natural products for inhibitors of quinone reductase-2 using ultrafiltration LC-MS. Anal Chem. 2011 Feb 1;83(3):1048-52. [2]. Tronina T, et al. Fungal metabolites of xanthohumol with potent antiproliferative activity on human cancer cell lines in vitro. Bioorg Med Chem. 2013 Apr 1;21(7):2001-6.