Penciclovir Sodium

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Penciclovir Sodium

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

97845-62-0

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品名称

VSA 671 sodium
BRL 39123A
BRL 39123D

产品介绍

Penciclovir (VSA 671) sodium 是一种有效的选择性抗疱疹病毒 (anti-herpesvirus) 剂，对于 HSV-1（HFEM），HSV-2（MS）的EC₅₀值分别为 0.5, 0.8 μg/ml。Penciclovir sodium 显示抗疱疹病毒活性且无细胞毒性。Penciclovir sodium 可防止小鼠死亡。

生物活性

Penciclovir (VSA 671) sodium is a potent and selectiveanti-herpesvirusagent withEC₅₀values of 0.5, 0.8 μg/ml forHSV-1(HFEM),HSV-2(MS), respectively. Penciclovir sodium shows anti-herpesvirus activity with no-toxic. Penciclovir sodium preventes mortality in mouse^[1]^[2].

IC₅₀& Target^[1]

HSV-1

0.5 μg/mL (EC₅₀)

HSV-2

0.8 μg/mL (EC₅₀)

体外研究
(In Vitro)

Penciclovir sodium (0-100 μg/ml) shows anti-herpesvirus activity with EC₅₀s of 0.5, 0.8, 2.4, 52, 100, 1.2, 1.6, 0.9, >100 μg/ml for HSV-1 (HFEM), HSV-2 (MS), VZV (Ellen), CMV (AD-169), BHV-1 (Oxford 1964), BHV-2 (New York 1), EHV-1(Quai Hals), FHV-1 (B927), SVV, respectively^[1].
Penciclovir sodium (0-100 μg/ml) shows no-toxic to uninfected human cells^[1].

Cell Cytotoxicity Assay^[1]

Cell Line:	MRC-5,WISH, Flow 4000, Flow 12000, RPMI 2650, WI-38, WI-38 VA13, Hs68, HEp-2, RD, SCC-13,Primary cells
Concentration:	0-100 μg/ml
Incubation Time:
Result:	Showed no-toxic with IC₅₀s of >100, >100, 100, >100, 60, >100, >100, >100, >100, >100, >100, >100 for MRC-5,WISH, Flow 4000, Flow 12000, RPMI 2650, WI-38, WI-38 VA13, Hs68, HEp-2, RD, SCC-13,Primary cells, respectively.

体内研究
(In Vivo)

Penciclovir sodium (100 mg/kg; s.c.; daily for 5 days) preventes mortality in mouse^[2].

Animal Model:	Three-week-old female Balb/c mice^[2]
Dosage:	100 mg/kg
Administration:	S.c.; daily for 5 days
Result:	Reduced virus titres in the respiratory organs of both w/t- and PR3-infected mice.

Clinical Trial

分子量

275.24

Formula

C₁₀H₁₄N₅NaO₃

CAS 号

97845-62-0

中文名称

喷昔洛韦钠

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.