(±)11(12)-EET

立即咨询

(±)11(12)-EET

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

123931-40-8

包装与价格：

包装	价格(元)
25 μg	电议
50 μg	电议

产品名称

11,12-EET

产品介绍

(±)11(12)-EET 是 NLRP3 炎性小体抑制剂。(±)11(12)-EET 可用于抗炎、血管新生和心脏保护的研究。

生物活性

(±)11(12)-EET is aNLRP3inflammasome inhibitor. (±)11(12)-EET can be used for the research of anti-inflammatory, angiogenic and cardioprotective^[1]^[2]^[3]^[4]^[6].

IC₅₀& Target^[1]

NLRP3 inflammasome

体外研究
(In Vitro)

(±)11(12)-EET (5 μM; 10 mimutes; macrophages) depresses NLRP3 protein expression, dramatically decreases the expression of pro-IL-1β in cells and the supernatant and reduces the intracellular ROS^[1].

Western Blot Analysis^[1]

Cell Line:	Macrophages
Concentration:	5 μM
Incubation Time:	10 mimutes
Result:	Depresses NLRP3 protein expression.

Immunofluorescence^[1]

Cell Line:	Macrophages
Concentration:	5 μM
Incubation Time:	10 mimutes
Result:	Reduced the intracellular ROS.

体内研究
(In Vivo)

(±)11(12)-EET increases adhesion of isolated peripheral blood leukocytes in a chamber coated with P-selectin and ICAM-1 in 50 μg/kg^[5].

分子量

320.47

Formula

C₂₀H₃₂O₃

CAS 号

123931-40-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.