Ajmalicine (Raubasine) hydrochloride is a potentadrenolyticagent which preferentially blocksα₁-adrenoceptor. Ajmalicine hydrochloride is an reversible but non-competitivenicotine receptorfull inhibitor, with anIC₅₀of 72.3 μM. Ajmalicine hydrochloride also can be used as anti-hypertensive, and serpentine, with sedative activity^[1][2].

Ajmalicine hydrochloride preferentially blocksα₁-adrenoceptorthan α₂-adrenoceptor^[1].
Ajmalicine hydrochloride inhibits contractions in a concentration-dependent manner (IC₅₀=72.3 ± 22.5 μM)^[2].
Ajmalicine hydrochloride acts preferentially at postsynaptic sites, competitively antagonizes the effect of noradrenaline on postsynaptic alpha-adrenoceptor with a pA2 value of 6.57, blocks the inhibitory effect of clonidine with an pA2 value of 6.2^[3].

Ajmalicine hydrochloride blocking the pressor action of electrical stimulation and is active against sympathetic stimulation^[1].
Ajmalicine hydrochloride (0.5-4 mg/kg) induces a marked dose-dependent inhibition against the pressor response to noradrenaline^[1].

388.89

C₂₁H₂₅ClN₂O₃

4373-34-6

• Alkaloids
• Other Alkaloids

• Plants
• Rosaceae
• Rosa multifoloraThunb

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