Hirsutine, an indole alkaloid ofUncaria rhynchophylla, exhibits anti-cancer activity. Hirsutine inducesapoptosisand is a potent Dengue virus inhibitor exhibiting low cytotoxicity^[1][2][3].

Hirsutine remarkably reduces the viability of MCF-7 and MDA-MB-231 cells in a time- and dose-dependent manner with IC₅₀values of 447.79 and 179.06 μM, respectively. In the MDA-MB-231 cells, Hirsutine induces apoptosis and depolarization of MMP, releases Cyt C from mitochondria, and activates caspase 9 and caspase 3^[2].

Hirsutine induces mPTP-dependent apoptosis through ROCK1/PTEN/PI3K/GSK3β pathway in human lung cancer cells^[3].

368.47

Solid

C₂₂H₂₈N₂O₃

7729-23-9

毛钩藤碱； 毛帽柱木碱； 二氢柯楠因碱； 陆地棉苷

• Alkaloids
• Indole Alkaloids

• Plants
• Rubiaceae
• Uncaria rhynchophylla(Miq.) Miq. ex Havil.

Room temperature in continental US; may vary elsewhere.

DMSO : 100 mg/mL(271.39 mM;Need ultrasonic)

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储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。