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Deoxylimonin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Deoxylimonin图片
CAS NO:989-23-1
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
Desoxylimonin 是一种具有口服活性的三萜类化合物,可从葡萄柚种子中发现。Desoxylimonin 对乳腺癌细胞有抗增殖活性,其衍生物显示出更好的抗癌、镇痛和抗炎活性。
生物活性

Desoxylimonin is an orally active triterpenoid compound found from grapefruit seed. Desoxylimonin shows anti-proliferative activities to breastcancercells. Desoxylimonin derivatives shows better anticancer, analgesic and anti-inflammatory activity than the lead compound[1].

体外研究
(In Vitro)

Deoxylimonin (0-90 μg/mL, 48 h) treatment shows anti-proliferation activities to breast cancer cells[2].

Cell Proliferation Assay[2]

Cell Line:MDA-MB-435 and MCF-7 cells
Concentration:0-90 μg/mL
Incubation Time:48 hours
Result:Showed IC50values of 0.78 μg/mL and 2.50 μg/mL for MDA-MB-435 and MCF-7 cells, respectively.
体内研究
(In Vivo)

Deoxylimonin (oral administration; 70 mg/kg; once) treatment shows antinociception effects in vivo[1].

Animal Model:Mice injected with acetic acid[1]
Dosage:70 mg/kg
Administration:Oral administration; 70 mg/kg; once
Result:Showed the antinociception efficacy (writhing inhibition rate: 24.61%).
分子量

454.51

性状

Solid

Formula

C26H30O7

CAS 号

989-23-1

结构分类
  • Terpenoids
  • Triterpenes
来源
  • Plants
  • Rutaceae
  • Citrus paradisiMacf.

Acinetobacter species

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
In Vitro: 

DMSO : 100 mg/mL(220.02 mM;Need ultrasonic)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM2.2002 mL11.0009 mL22.0017 mL
5 mM0.4400 mL2.2002 mL4.4003 mL
10 mM0.2200 mL1.1001 mL2.2002 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month (protect from light)。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。