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Niga-ichigoside F1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Niga-ichigoside F1图片
CAS NO:95262-48-9
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议

产品名称
苦莓苷F1
产品介绍
Niga-ichigoside F1 是一种具有口服活性熊果三萜,具有抗高血脂和抗氧化活性。Niga-ichigoside F1 可以预防高脂肪饮食 (HFD) 诱导的肝脂肪变性。
生物活性

Niga-ichigoside F1, an orally active ursane triterpenoid, has antihyperlipidemic and antioxidant activities. Niga-ichigoside F1 can prevent high-fat diet (HFD)-induced hepatic steatosis[1].

体外研究
(In Vitro)

Niga-ichigoside F1 (2.5, 5, 10, 20 μM; for 24 hours) inhibits lipid accumu-lation in free fatty acid (FFA)-treated HepG2 cells in a dose-dependent manner. Niga-ichigoside F1 has no effects on cell viability[1].
Both nuclear and cytoplasmic Nrf2 expressions are lowered in Con, Niga-ichigoside F1 (20 μM), FFA (1 mM), and Niga-ichigoside F1 plus FFA treated Nrf2-silenced cells[1].

体内研究
(In Vivo)

Niga-ichigoside F1 (40 mg/kg; oral gavage; for 12 weeks) alleviates hepatic steatosis, possibly by significantly interacting with high-fat diet (HFD) to regulate lipid metabolism genes (including Srebp1c, Acc1, Fasn, Scd1, Cpt1a and Fabp5) in four-week-old male C57BL/6J mice[1].

分子量

666.84

性状

Solid

Formula

C36H58O11

CAS 号

95262-48-9

中文名称

苦莓苷F1

结构分类
  • Terpenoids
  • Triterpenes
来源
  • Plants
  • Compositae
  • Inula sericophyllaFranch.
  • Plants
  • Labiatae
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)