| CAS NO: | 186545-76-6 |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| Cas No. | 186545-76-6 |
| 化学名 | N-(phenylmethyl)-ethanimidamide, monohydrobromide |
| Canonical SMILES | CC(NCC1=CC=CC=C1)=N.Br |
| 分子式 | C9H12N2· HBr |
| 分子量 | 229.1 |
| 溶解度 | ≤25mg/ml in ethanol;15mg/ml in DMSO;20mg/ml in dimethyl formamide |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | IC50: 0.20 μM: inhibits inducible nitric oxide synthases (iNOS). IC50: 350 μM: blocks endothelial nitric oxide synthases (eNOS). N-Benzylacetamidine is a potent and selective inhibitor of iNOS compared to eNOS. NOS is essential to the formation of nitric oxide (NO) via the NADPH- and O2-dependent oxidation of L-arginine, which plays a role in regulating many pathological and physiological processes, including smooth muscle relaxation and neurotransmission. INOS contributes to immune response and inflammation while eNOS plays a vital role in regulating vascular tone. In vitro: N-Benzylacetamidine showed good iNOS and almost negligible eNOS inhibition in THP-1 cells, a human myelomonocytic leukemia cell line [1]. In vivo: Up to now, in vivo study of N-Benzylacetamidine is still in the development stage. Reference: |
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