| Cas No. | 15136-34-2 |
| 化学名 | 3S-(1H-indol-3-ylmethyl)-6S-(2-methylpropyl)-2,5-piperazinedione |
| Canonical SMILES | O=C([C@H](CC(C)C)N1)N[C@@H](CC2=CNC3=C2C=CC=C3)C1=O |
| 分子式 | C17H21N3O2 |
| 分子量 | 299.4 |
| 溶解度 | Methanol: Soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Cyclo(L-Leu-L-Trp) is a diketopiperazine metabolite originally isolated from Penicillium. It is active against various bacteria (MICs = 125-1000 ug/ml) and fungi (MICs = 8-64 ug/ml), and it inhibits the production rate of hydroxy radicals in an electron spin resonance (ESR) spectroscopy-based assay (IC50 = 1.8 uM). Cyclo(L-Leu-L-Trp) is a bitter tastant that can rapidly permeate rat taste cell membranes ex vivo when used at a concentration of 1 mM. It also acts as a melatonin receptor agonist in X. laevis melanophores, inhibiting cAMP accumulation when used at a concentration of 20 uM, an effect that is blocked by the melatonin receptor antagonist luzindole . |
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