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PRATENSEIN
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PRATENSEIN图片
CAS NO:2284-31-3
包装与价格:
包装价格(元)
1mg电议
2mg电议
5mg电议
10mg电议

产品介绍
Pratensein 是一种黄酮类化合物,通过减少氧化损伤和恢复突触和 BDNF 水平来改善 β-淀粉样蛋白诱导的大鼠认知障碍。
生物活性

Pratensein, a flavonoid, ameliorates β-amyloid-induced cognitive impairment in rats via reducing oxidative damage and restoring synapse and BDNF levels[1].

体内研究
(In Vivo)

Pratensein significantly attenuates neuronal degeneration and apoptosis in hippocampus. The over-expression in IL-1β and TNF-α as well as the extensive astrogliosis and microgliosis in hippocampus induced by Aβ1-42 are significantly reduced following administration of Pratensein. Pratensein treatment significantly suppresses the activation of NF-κB in hippocampus. Pratensein is able to increase the levels of synaptophysin and brain-derived neurotrophic factor (BDNF)[1].
Pratensein (20 mg/kg; p.o.; once daily for 3 weeks) ameliorates learning and memory deficits in Aβ1-42 rat model of Alzheimer’s disease[1].

Animal Model:Male 10-week old Wistar rats[1]
Dosage:20 mg/kg
Administration:P.o.; once daily for 3 weeks
Result:The spatial learning and memory ability of rats was improved.
分子量

300.26

性状

Solid

Formula

C16H12O6

CAS 号

2284-31-3

结构分类
  • Flavonoids
  • Isoflavones
  • Phenols
  • Polyphenols
来源
  • Plants
  • Leguminosae
  • Trifolium pratenseL.
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
In Vitro: 

DMSO : 50 mg/mL(166.52 mM;Need ultrasonic)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM3.3304 mL16.6522 mL33.3045 mL
5 mM0.6661 mL3.3304 mL6.6609 mL
10 mM0.3330 mL1.6652 mL3.3304 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture and light)。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。