您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > Bakkenolide B
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Bakkenolide B
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Bakkenolide B图片
CAS NO:18455-98-6
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
Bakkenolide B 是从petasites japonicas叶片中分离出来的,具有抗过敏和抗炎作用。 Bakkenolide B 可用于研究哮喘。
生物活性

Bakkenolide B is isolated frompetasites japonicasleaves and has anti-allergic and anti-inflammatory effects. Bakkenolide B can be used for the study of asthma[1].

体外研究
(In Vitro)

Bakkenolide B (0-100 μg/ml; pretreatment 30 mins) inhibits antigen-induced β-hexosamidase release from RBL2H3 mast cells in a concentration-dependent manner[1].
Bakkenolide B (0-10 μg/ml; 1 h later stimulated with LPS) strongly inhibits the gene inductions of inducible nitric oxide synthase and cyclooxygenase-2 in a concentration-dependent manner in mouse peritoneal macrophages[1].

Western Blot Analysis[1]

Cell Line:Mouse peritoneal macrophages
Concentration:0 μg/ml; 1 μg/ml; 3 μg/ml; 5 μg/ml; 10 μg/ml
Incubation Time:1 h later stimulated with LPS
Result:Decreased iNOS and cox-2 protein expression.
体内研究
(In Vivo)

Bakkenolide B (intraperitoneal injection; 1 mg/ml; 1 h before ovalbumin nebulization on days 28, 29, and 30) strongly inhibits the accumulation of eosinophils, macrophages, and lymphocytes to bronchoalveolar lavage fluid (BALF) in ovalbumin-induced asthma mice[1].

Animal Model:Ovalbumin-induced asthma mice[1]
Dosage:1 mg/ml
Administration:Intraperitoneal injection; 1 h before ovalbumin nebulization on days 28, 29, and 30
Result:Exhibited anti-allergic effects in mice.
分子量

390.47

Formula

C22H30O6

CAS 号

18455-98-6

结构分类
  • Terpenoids
  • Other Terpenoids
来源
  • Plants
  • Leguminosae
  • PiptadeniaBenth.
  • Plants
  • Compositae
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.