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Biperiden HCl
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Biperiden HCl图片
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
25mg电议
100mg电议
500mg电议

产品介绍
Biperiden (KL 373) hydrochloride 是一种非选择性毒蕈碱受体拮抗剂,可与 M1 毒蕈碱受体竞争性结合,从而抑制乙酰胆碱并增强中枢神经系统中的多巴胺信号传导。

Animal models

Male Lister Hooded rats model;

Dosage form

3, and 10 mg/kg; intraperitoneal injection; for 90 min; or 4 mg, oral administration

Applications

Biperiden HCl acted as cognition impairer in rats and Biperiden (10 mg/kg) induced side-effects, with rats taking more time to start the task [1]. Moreover, oral doses of 4 mg of Biperiden HCl reached a Cmax of approximately 4 ng/mL [2].

Other notes

Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal.

产品描述

Biperiden HCl is an anticholinergic drug [1].

As an anticholinergic drug, biperiden is first used in the treatment of Parkinson's disease. It is a competitive antagonist of muscarinic receptor. It has been believed that in the patients of PD, a reduction of intranigral dopamine concentrations results in a relative imbalance between the dopaminergic and cholinergic neurological pathways. The anticholinergics can correct the imbalance through reducing the degree of neurotransmission mediated by neostriatal acetylcholine. Biperiden is also used to treat extrapyramidal side effects of antipsychotic drugs. In addition, the misuse of biperiden causing delirium has been reported in several clinical settings [1, 2].

References:
[1] Brocks D R. Anticholinergic drugs used in Parkinson’s disease: an overlooked class of drugs from a pharmacokinetic perspective. J Pharm Pharm Sci, 1999, 2(2): 39-46.
[2] Espi Martinez F, Espi Forcen F, Shapov A, et al. Biperiden Dependence: Case Report and Literature Review. Case reports in psychiatry, 2012, 2012.